H. Y. Kim, T. R. Jackson, C. Stuckenholz, and L. A. Davidson (submitted, bioRxiv). Tissue mechanics drives epithelialization, goblet cell regeneration, and restoration of a mucociliated epidermis on the surface of embryonic aggregates. here
S. J. Smith, L. A. Davidson, and M. Rebeiz (submitted, bioRxiv). Expansion of apical extracellular matrix underlies the morphogenesis of a recently evolved structure. here
T. L. Stepien, H. E. Lynch, S. X. Yancey, L. Dempsey, and L. A. Davidson (2019). Using a continuum model to decipher the mechanics of embryonic tissue spreading from time-lapse image sequences: An approximate Bayesian computation approach. PLoS One. DOI.10.1371/journal.pone.0218021
H. B. Wolff, L. A Davidson, and R. M. H. Merks (2019). Adapting a plant tissue model to animal development: introducing cell sliding into VirtualLeaf. Special Issue: Multiscale Modeling of Tissue Growth and Shape. Bulletin of Mathematical Biology. 1-20.
T. R. Arnold, J. H. Shawky, R. E. Stephenson, K. M. Dinshaw, T. Higashi, F. Huq, L. A. Davidson, and A. L. Miller (2019). Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network. ELife. eLife 2019;8:e39065 PMID: 30702429.
G. Ingram, and L. A. Davidson (2018). Perspective on special issue “Developmental mechanisms, patterning and evolution”. Current Opinion in Genetics and Development. 51: iii-v. PMID: 30501872. DOI: 10.1016/j.gde.2018.11.001
S. J. Smith, M. Rebeiz, and L. A. Davidson (2018). From pattern to process: studies at the interface of gene regulatory networks, morphogenesis, and evolution. Current Opinion in Genetics and Development. 51: 103-110. PMID: 30278280. DOI: 10.1016/j.gde.2018.08.004
C. J. Miller, D. Harris, R. Weaver, B. Ermentrout, L. A. Davidson (2018). Emergent mechanics of actomyosin drive cortical contractions and shape network morphology. PLoS Computational Biology. PMID: 30222728. PMCID: PMC6171965. DOI: 10.1371/journal.pcbi.1006344
J. H. Shawky, U. L. Balakrishnan, C. Stuckenholz, L. A. Davidson (2018). Multiscale analysis of architecture, cell size and the cell cortex reveals cortical F-actin density and composition are major contributors to mechanical properties during convergent extension. Development.145(19). pii: dev161281. PMID: 30190279. PMCID: PMC6198471. DOI: 10.1242/dev.161281
B. López-Escobar, J. Caro, D. S. Vijayraghavan, T. F. Plageman, J.A. Sanchez-Alcazar, R. C. Moreno, D. Savery, A. J. Copp, J. Marquez, L. A. Davidson, P. Ybot-González (2018). The non-canonical Wnt-PCP pathway shapes the caudal neural plate. Development. PMID: 29636380. PMCID: PMC5992595. DOI: 10.1242/dev.157487
D. R. Shook, E. M. Kasprowicz, L. A. Davidson, and R. Keller (2018). Large, long range convergence forces are generated around the blastopore during early Xenopus morphogenesis. eLife, 7, e26944. PMID: 29533180. PMCID: PMC5896886.
T. R. Jackson, H. Y. Kim, U. L. Balakrishnan, C. Stuckenholz, and L. A. Davidson (2017). Spatiotemporally controlled mechanical cues drive progenitor mesenchymal-to-epithelial transition enabling proper heart formation and function. Current Biology. 27: 1326–1335. PMID: 28434863 PMCID: 5497766
S. Chanet, S., C. J. Miller, E. D. Vaishnav, B. Ermentrout, L. A. Davidson, & A. C. Martin (2017). Actomyosin meshwork mechanosensing enables tissue shape to orient cell force. Nature Communications, 8. PMID: 28504247, PMCID: 5440693,
L. A. Davidson (2017). Mechanical design in embryos: mechanical signaling, robustness, and developmental defects. Philosophical Transactions of the Royal Society, Part B. Special Issue on Morphogenesis. PMID: 28348252 PMCID: PMC5379024
G. A. Stooke-Vaughan, L. A. Davidson, and S. Woolner (2017). Xenopus as a model for studies in mechanical stress and cell division. Genesis, The Journal of Genetics and Development. PMID: 28095623 PMCID: PMC5276720
D. Vijayraghavan and L. A. Davidson (2016). Mechanics of Neurulation: from classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube. Birth Defects Research Part A: Clinical and Molecular Teratology. PMID: 27620928
J. J. Adibi, Y. Zhao, A. Cartus, P. Gupta, and L. A. Davidson (2016). Placental mechanics in the Zika-microcephaly relationship. Cell Host & Microbe, 20(1), 9-11. Commentary on recent studies. PMID:27414496
H. Y. Kim*, T. R. Jackson*, and L. A. Davidson (2016). On the role of mechanics in driving mesenchymal-to-epithelial transitions. (* contributed equally) Seminars in Cell and Developmental Biology. PMID:27208723
B. Holt, J. H. Shawky, K. N. Dahl, L. A. Davidson§, M. Islam§ (2016). Distribution of single-wall carbon nanotubes in the Xenopus laevis embryo after microinjection. Applied Toxicology. 36: 568-578. (§ contributed equally) PMID: 26510384.
B. Holt, J. H. Shawky, K. N. Dahl, L. A. Davidson§, M. Islam§ (2016). Developing Xenopus embryos recover by compacting and expelling single-wall carbon nanotubes. Journal of Applied Toxicology. 36: 579-585. (§ contributed equally). PMID: 26153061
2015 and earlier
M. Hazar, Y.T. Kim, J. Song, P.R. LeDuc, L.A. Davidson, and W.C. Messner (2015). 3D Bio-etching of a Complex Composite-like Embryonic Tissue. Lab on a Chip. 15(16):3293-9. PMID: 26138309
J. Song, J. H. Shawky, Y. T. Kim, M. Hazar, P. R. LeDuc, M. Sitti, and L. A. Davidson (2015). Controlled surface topography regulates collective 3D migration by epithelial-mesenchymal composite embryonic tissues. Biomaterials, 58: 1-9. PMID: 25933063
J. Zhou, S. Pal, S. Maiti, and L. A. Davidson (2015). Force production and mechanical accommodation during convergent extension. Development. 142, 692-701. PMID: 25670794.
J. H. Shawky and L. A. Davidson (2015). Tissue mechanics and adhesion during embryo development. Developmental Biology. 401: 152-164. (Special Issue on Adhesion). PMID: 25512299.
E. M. McGreevy. D. Vijayraghavan, L. A. Davidson and J. D. Hildebrand (2015). Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Biology Open . PMID: 25596276.
R. Feroze*, J. H. Shawky*, M. von Dassow, and L. A. Davidson (2015). Mechanics of blastopore closure during amphibian gastrulation. (* contributed equally) Developmental Biology. 398(1):57-67. PMID: 25448691.
Y. T. Kim, M. Hazar, D. Vijayraghavan, J. Song, T. R. Jackson, S. D. Joshi, L. A. Davidson§, W. C. Messner§, and P. R. LeDuc§. (2014) Mechanochemical actuators of embryonic epithelial contractility. (§ contributed equally) Proceedings of the National Academy of Sciences. 111, 14366-14371. PMID: 25246549.
M. von Dassow, C. J. Miller, and L. A. Davidson (2014). Biomechanics and the thermotolerance of development. PLoS ONE. 9: e95670. PMID: 24776615.
A. F. Edlund, L. A. Davidson, and R. E. Keller. (2013). Cell segregation, mixing, and tissue pattern in the spinal cord of the Xenopus laevis neurula. Developmental Dynamics. 242:1134-46. PMID: 23813905
H. Y. Kim, and L. A. Davidson. (2013). Assembly of chambers for stable long-term imaging of live Xenopus tissue. Cold Spring Harbor Protocols, pdb. prot073882. PMID: 23547159
H. Y. Kim, and L. A. Davidson. (2013). Investigating morphogenesis in Xenopus embryos: Imaging strategies, processing, and analysis. Cold Spring Harbor Protocols, pdb. top073890. PMID: 23547160
H. Y. Kim, and L. A. Davidson. (2013). Microsurgical approaches to isolate tissues from Xenopus embryos for imaging morphogenesis. Cold Spring Harbor Protocols, pdb. prot073874. PMID: 23547158
H. Y. Kim, and L. A. Davidson. (2013). Preparation and use of reporter constructs for imaging morphogenesis in Xenopus embryos. Cold Spring Harbor Protocols, pdb. prot073866. PMID: 23547157
L. A. Davidson (2012). No strings attached: new insights into epithelial morphogenesis. BMC Biology. 10:105. (pubmed)
S. D. Joshi and L. A. Davidson (2012). Epithelial machines of morphogenesis and their potential application in organ assembly and tissue engineering. Biomechanics and Modeling in Mechanobiology. 11:1109-21. (pubmed)
L. A. Davidson and B. Baum (2012). Making waves: the rise and fall and rise of quantitative developmental biology. Development 139:3065-9. (pubmed)
S. D. Joshi* , H. Y. Kim* , and L. A. Davidson (2012). Microscopy tools for quantifying developmental dynamics in Xenopus embryos. In Hoppler, S and Vize, P.D. (Editors). Xenopus Protocols, Second Edition. Methods in Molecular Biology 917:477-93 Springer. (* contributed equally) (pubmed)
C. J. Miller, G. B. Ermentrout§, L. A. Davidson§, (2012). Rotational model for actin filament alignment by myosin. Journal of Theoretical Biology. 300: 344-359. (§ contributed equally) (pubmed)
L. A. Davidson (2011). Epithelial machines that shape the embryo. Trends in Cell Biology. (pubmed)
S. M. Trier and L. A. Davidson (2011). Quantitative microscopy and imaging tools for the mechanical analysis of morphogenesis. Current Opinion in Genetics & Development 21:664-70 (pubmed)
M. von Dassow and L. A. Davidson (2011). Physics and the canalization of morphogenesis: a grand challenge in organismal biology. Physical Biology. 8: 045002. (pubmed)
Y. Kim, S. D. Joshi, L. A. Davidson, P. R. LeDuc, and W. C. Messner (2011). Dynamic control of 3D chemical profiles with a single 2D microfluidic platform. Lab on a Chip. 11: 2182-2188. (pubmed)
L. A. Davidson (2011). Embryo mechanics: balancing force-production with elastic resistance during morphogenesis. Chapter in “Forces and Tension in Developmental Biology” a special volume in Current Topics in Developmental Biology. 95: 215-241. (ed. by Michel Labouesse). (pubmed)
L. A. Davidson (2011). The physical mechanical processes that shape tissues in the early embryo. Chapter in “Cellular and Biomolecular Mechanics and Mechanobiology.” (ed. by Amit Gefen) Springer Studies in Mechanobiology, Tissue Engineering and Biomaterials. (springer)
K. V. Upadhye, J. E. Candiello, L. A. Davidson, H. Lin. (2011) Whole-cell electrical activity under direct mechanical stimulus by AFM cantilever using planar patch clamp chip approach. Cellular and Molecular Bioengineering. 4: 270-280. (ingenta)
Y. Kim*, S. D. Joshi*, W. C. Messner, P. R. LeDuc, L. A. Davidson (2011). Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue.. (* contributed equally) PLoS ONE. 6: e14624. (pubmed)
H. Y. Kim and L. A. Davidson (2011). Punctuated actin contractions during convergent extension and their permissive regulation by the non-canonical Wnt-signaling pathway. Journal of Cell Science. 124: 635 – 646. (Article rated “Must Read” by Faculty of 1000 Biology). (pubmed)
M. von Dassow, J. A. Strother, and L. A. Davidson (2010). Surprisingly simple mechanical behavior of a complex embryonic tissue. PLoS ONE. 5: e15359. (pubmed)
H. Y. Kim and L. A. Davidson (2010). Methods to investigate molecular mechanisms and cellular mechanics responsible for morphogenesis in Xenopus laevis embryos. Chapter in Imaging in Developmental Biology: A Laboratory Manual. (ed. by Rachel Wong and James Sharpe), Cold Spring Harbor Laboratory Press, NY. (cshlpress)
J. Zhou*, H. Y. Kim*, J. H-C. Wang, and L. A. Davidson (2010). Macroscopic stiffening of embryonic tissues via microtubules, Rho-GEF, and assembly of contractile bundles of actomyosin. Development 137: 2785 – 2794.(* contributed equally; article featured in Issue’s “Highlights” section and rated “Exceptional” by John Wallingford for Faculty of 1000 Biology). (pubmed)
S. D. Joshi and L. A. Davidson (2010). Live-cell imaging and quantitative analysis of embryonic epithelial cells in Xenopus laevis. Journal of Visual Experimentation (JoVE) 39: pii: 1949. (pubmed)
L. A. Davidson, S. D. Joshi, H. Y. Kim, M. von Dassow, L. Zhang, and J. Zhou (2010). Emergent morphogenesis: elastic mechanics of a self-deforming tissue. Journal of Biomechanics 43:63-70. (article appears in the Special Issue “Innovations in Cell Mechanobiology”.) (pubmed)
S. D. Joshi*, M. von Dassow*, and L. A. Davidson (2009). Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction. Experimental Cell Research. (* equal contributions) (pubmed)
M. A. Edeling, S. Sanker, T. Shima, P.K. Umasankar, S. Höning, H. Y. Kim, L. A. Davidson, S. C. Watkins, M. Tsang, D. J. Owen, and L. M. Traub (2009). Structural requirements for PACSIN/Syndapin operation during embryonic notochord development. PLOS One 4:e8150. (pubmed)
X. Yang, J. Zou, D. Hyde, L. Davidson, and X. Wei (2009). Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. Journal of Neuroscience 29:11426-11440 (article featured in Issue’s “Highlights” section). (pubmed)
L. A. Davidson, M. von Dassow, and J. Zhou (2009). Multi-scale mechanics from molecules to morphogenesis. International Journal of Biochemistry and Cell Biology. (pubmed)
J. Zhou, H. Y. Kim, and L. A. Davidson (2009). Actomyosin stiffens the vertebrate embryo during critical stages of elongation and neural tube closure. Development 136: 677-688. (article featured by Thomas Lecuit in Faculty of 1000 and rated 6.0, a “Must Read”) (pubmed)
M. von Dassow and L. A. Davidson (2009). Natural variation in embryo mechanics: gastrulation in Xenopus laevis is highly robust to variation in tissue stiffness. Developmental Dynamics 238: 2-18. (article featured in May 2009 Dev. Dyn. “Highlights” section) (pubmed)
T. Rozario, B. Dzamba, G. F. Weber, L. A. Davidson, and D. W. DeSimone (2009) The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo. Developmental Biology 327:386-98. (pubmed)
L. A. Davidson (2008). Apoptosis turbocharges epithelial morphogenesis. Science, 321:1641-1642. (pubmed)
L. A. Davidson, B. D. Dzamba, R. Keller, and D. W. DeSimone (2008). Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis. Developmental Dynamics 237: 2684-2692. (pubmed)
L. A. Davidson (2008). Taming the tiger of tissue aggregation: How epithelia control structural assembly of underlying cells. Developmental Cell 14: 152-154. (pubmed)
M. von Dassow and L. A. Davidson (2008). Variation and robustness of the mechanics of gastrulation: the role of tissue mechanical properties during morphogenesis. Birth Defects Research Part C: Embryo Today. 81: 253-269. (pubmed)
K. Koide, F. Song, E.D. de Groh, A.L. Garner, V.D. Mitchell, L.A. Davidson, and N.A. Hukriede (2008) Scalable and concise synthesis of water-soluble dichlorofluorescein derivatives displaying tissue permeability in live zebrafish embryos. ChemBioChem 9:214-8. (pubmed)
L. A. Davidson (2008). Integrating morphogenesis with underlying mechanics and cell biology. Current Topics in Developmental Biology. 81:113-33. (pubmed)
J. B. A. Green and L. A. Davidson (2007). Convergent extension and the hexahedral cell. Nature Cell Biology, 9:1010-1015. (paper featured in editorial commentary p.983 of same issue). (pubmed)
D. W. DeSimone, B. Dzamba, and L. A. Davidson (2007). Using Xenopus embryos to investigate integrin function. Chapter in Methods in Enzymology. Vol. 426. (ed. by David Cheresh) (pubmed)
L. A. Davidson and R. E. Keller (2007). Measuring mechanical properties of embryos and embryonic tissues. Chapter in Methods in Cell Biology: Cell Mechanics vol. 83 (ed. by Y.-L. Wang and D. E. Discher) (pubmed)
L. B. Benseñor, H.-M. Kan, N. Wang, H. Wallrabe, L. A. Davidson, Y. Cai, D. A. Schafer, and G. S. Bloom (2007). IQGAP1 Regulates Cell Motility by Linking Growth Factor Signaling to Actin Assembly. Journal of Cell Science, 120: 658-669. (pubmed)
J. Stubbs, L. Davidson, R. Keller, and C. Kintner (2006). Radial intercalation of ciliated cells during Xenopus skin development. Development, 133: 2507-15 (pubmed)
L. A. Davidson, M. Marsden, R. Keller, and D.W. DeSimone (2006). Integrin a5b1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension. Current Biology, 16: 833-844. (pubmed)
T. Goto*, L. A. Davidson*, and R. E. Keller (2005). Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. Current Biology, 15: 787-793. (* equal contributions) (pubmed)
L. A. Davidson and J. B. Wallingford (2005). Visualizing morphogenesis in the frog embryo. Chapter in Imaging in Neuroscience and Development: a Laboratory Manual. (ed. by R. Yuste and A. Konnerth), 2003, Cold Spring Harbor Laboratory Press, NY.
D. W. DeSimone, L. A. Davidson, M. Marsden, and D. Alfandari (2005) The Xenopus embryo as a model system for studies of cell migration. Chapter in Methods in Molecular Biology: Cell Migration in Development. (ed. by Jun Lin Guan), Humana Press, Totowa, NJ. (pubmed)
L. A. Davidson, R. Keller, and D. W. DeSimone (2004). Assembly and remodeling of fibrillar fibronectin extracellular matrix during gastrulation and neurulation in Xenopus laevis. Developmental Dynamics, 231: 888-95. (pubmed)
M. C. Lane, L. A. Davidson, and M. D. Sheets (2004). BMP antagonists from Spemann’s organizer rostralize dorsal mesoderm. Developmental Biology, 275: 356-374. (pubmed)
J. B. A. Green, I. Dominguez, and L. A. Davidson (2004). Self-organization of vertebrate mesoderm based on simple boundary conditions. Developmental Dynamics, 231: 576-81. (pubmed)
L. A. Davidson, R. Keller, and D. W. DeSimone (2004). Patterning and tissue movements in a novel explant of the marginal zone of Xenopus laevis. Gene Expression Patterns in Mechanisms of Development, 4: 457-466. (pubmed)
D. Longo, S. M. Peirce, T. C. Skalak, L. A. Davidson, M. Marsden, B. Dzamba, and D. W. DeSimone (2004). Multicellular computer simulation of morphogenesis: blastocoel roof thinning and matrix assembly in Xenopus laevis. Developmental Biology, 271: 210-222. (pubmed)
R. Keller and L. A. Davidson (2004) Cell Movements. Chapter in Gastrulation: from Cells to Embryo (ed. C. Stern), 2004 Cold Spring Harbor Laboratory Press, NY.
R. Keller and L. A. Davidson. (2004). Cell crawling, cell behavior and biomechanics during convergence and extension. Chapter in Cell Motility: From Molecules to Organisms. (ed. A. Ridley, P. Clark, and M. Peckham), John Wiley & Sons.
R. Keller, L. A. Davidson, and D. R. Shook (2003). How we are shaped: the biomechanics of gastrulation. Differentiation, 71: 171-205. (pubmed)
L. A. Davidson, R. E. Keller, and D.W. DeSimone (2002). Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin a5b1, fibronectin and tissue geometry. Developmental Biology, 242: 109-129 (pubmed)
L. A. Davidson, M. Ezin, and R. E. Keller (2002). Wound healing by apical contraction and ingression in early Xenopus leavis embryos. Cell Motility and the Cytoskeleton, 53: 163- 176. (pubmed)
S. George, D. Evans, L. A. Davidson (2002). A biologically inspired programming model for self-healing systems. Paper contributed to Association for Computing Machinery – Workshop on Self-Healing Systems 2002, Charleston, SC. p. 102-104.
L. A. Davidson and R. E. Keller (2001). Basics of a Light Microscopy Imaging System and its Application in Biology. Chapter in Methods in Cellular Imaging (ed. A. Periasami; American Physiological Society Book Series), Oxford University Press.
R. Keller, L. A. Davidson, A. Edlund, T. Elul, M. Ezin, D. Shook, and P. Skoglund (2000). Mechanisms of convergence and extension by cell intercalation. Philosophical Transactions B: Biological Sciences, 355:897-922. (pubmed)
L. A. Davidson, R. E. Keller (1999). Neural tube closure in Xenopus leavis involves medial migration, directed protrusive activity, cell intercalation, and convergent extension. Development 126: 4547-4556. (pubmed)
L. A. Davidson, G.F. Oster, R. E. Keller, and M.A.R. Koehl (1999). Measurements of mechanical properties of the blastula wall reveal which hypothesized mechanisms of primary invagination are physically plausible in the sea urchin Strongylocentrotus purpuratus. Developmental Biology, 209: 221-238. (pubmed)
L. A. Davidson, M.A.R. Koehl, R. E. Keller, and G.F. Oster (1995). How do sea urchins gastrulate? Using biomechanics to distinguish between mechanisms of primary invagination. Development, 121(7): 2005-2018. (pubmed)