Category Archives: Uncategorized

T. Ichikawa, C. Stuckenholz, and L. A. Davidson (2019). Non-junctional Cadherin3 regulates cell migration and contact inhibition of locomotion via domain-dependent opposing regulation of Rac1. bioRxiv 750752 link

Kim, H. Y., Jackson, T. R., Stuckenholz, C., & Davidson, L. A. (2019). Tissue mechanics drives epithelialization, goblet cell regeneration, and restoration of a mucociliated epidermis on the surface of embryonic aggregates. bioRxiv, 696997. See link.

Smith, S. J., Davidson, L. A., & Rebeiz, M. (2019). Expansion of apical extracellular matrix underlies the morphogenesis of a recently evolved structure. bioRxiv, 686089. See link.

When constructing computational models of morphogenesis researchers typically identify single sets of “good” parameters. However, these sets are often just one of many “nearly-good” parameter sets. How can we use the torrent of imaging data to test the goodness of these parameter sets and establish more robust models? Check out Tracy and Holley’s paper in PLoS One to find out. See interview and Stepien, Lynch, et al. (2019).

We adapt modeling software developed for plant morphogenesis to modeling animal cells. We incorporated “bubbly” cell boundaries and a novel sliding vertex operator to overcome ill-defined conditions that drive vertex-jumping in convention spring-vertex models of epithelial sheets. See https://doi.org/10.1007/s11538-019-00599-9

Thanks to Dr. Roeland Merks, his wonderful lab, the kind folks of the Institute of Biology for hosting me.

Arnold, T. R., Shawky, J. H., Stephenson, R. E., Dinshaw, K. M., Higashi, T., Huq, F., … & Miller, A. L. (2019). Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network. ELife, 8, e39065. See link.