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Category Archives: Newly published

Mechanical control of mesenchymal-to-epithelial transitions.

2017-05-25 · Lance Davidson · Posted in Newly published ·

Newly Published: T. R. Jackson, H. Y. Kim, U. L. Balakrishnan, C. Stuckenholz, and L. A. Davidson (2017). Spatiotemporally controlled mechanical cues drive progenitor mesenchymal-to-epithelial transition enabling proper heart formation and function. Current Biology. 27: 1326–1335.

Describes a mesenchymal-to-epithelial transition (MET) in heart progenitor cells that is regulated by temporally specific mechanical cues originating from the endoderm. Accelerating or delaying MET by manipulating the mechanical microenvironment of the heart-forming region leads to abnormal heart anatomy
and function.

Actomyosin meshwork mechanosensing enables tissue shape to orient cell force.

2017-05-19 · Lance Davidson · Posted in Newly published ·

Newly Published: Chanet, S., Miller, C. J., Vaishnav, E. D., Ermentrout, B., Davidson, L. A. and Martin, A. C. (2017). Actomyosin meshwork mechanosensing enables tissue shape to orient cell force. Nature Communications 8. https://dx.doi.org/10.1038%2Fncomms15014

“Sculpting organism shape requires that cells produce forces with proper directionality. Thus, it is critical to understand how cells orient the cytoskeleton to produce forces that deform tissues.”

Mechanical design in embryos: mechanical signaling, robustness, and developmental defects.

2017-05-19 · Lance Davidson · Posted in Newly published ·

Newly Published: Davidson, L. A. (2017). Mechanical design in embryos: mechanical signalling, robustness and developmental defects. Phil. Trans. R. Soc. B 372, 20150516.

‘Embryology and morphology cannot proceed independently of all reference to the general laws of matter, to the laws of physics and of mechanics’.

—W. His in a letter to Professor Sir William Turner (1888) On the principles of animal morphology. Proc. R. Soc. Edinb. 15, 287–298.

Xenopus as a model for studies in mechanical stress and cell division.

2017-02-18 · Lance Davidson · Posted in Newly published ·

3.90 s

Newly Published: Stooke‐Vaughan, G., Davidson, L. and Woolner, S. (2017). Xenopus as a model for studies in mechanical stress and cell division. Genesis. – “We exist in a physical world, and cells within biological tissues must respond appropriately to both environmental forces and forces generated within the tissue to ensure normal development and homeostasis.  …”

New Publication with Sarah Woolner and Georgina Stooke-Vaughan!

2017-02-18 · Lance Davidson · 6,948 Comments · Posted in Newly published ·
dividing cells in epithelium

Stooke‐Vaughan, G. A., Davidson, L. A., & Woolner, S. (2017). Xenopus as a model for studies in mechanical stress and cell division. genesis, 55(1-2), e23004. See link.

Mechanics of neurulation: from classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube.

2016-09-14 · Lance Davidson · Posted in Newly published ·

brda-review-of-neurulation

New review published:  Vijayraghavan, D. S. and Davidson, L. A. (2016). Mechanics of neurulation: from classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube. Birth defects research. Part A, Clinical and molecular teratology. DOI: 10.1002/bdra.23557 .

Placental mechanics in the Zika-microcephaly relationship.

2016-07-31 · Lance Davidson · 6,336 Comments · Posted in All, Newly published ·

Commentary published with Dr. Jennifer Adibi and collaborators.

J. J. Adibi, Y. Zhao, A. Cartus, P. Gupta, and L. A. Davidson (2016).Placental mechanics in the Zika-microcephaly relationship. Cell Host & Microbe, 20(1), 9-11. Commentary on recent studies.

On the role of mechanics in driving mesenchymal-to-epithelial transitions

2016-07-01 · Lance Davidson · 2,290 Comments · Posted in All, Newly published ·

New review published in Seminars in Cell and Developmental Biology.

H. Y. Kim*, T. R. Jackson*, and L. A. Davidson (2016). On the role of mechanics in driving mesenchymal-to-epithelial transitions. (* contributed equally) Seminars in Cell and Developmental Biology.

 

On the role of mechanics in driving mesenchymal-to-epithelial transitions.

2016-07-01 · Lance Davidson · 1,811 Comments · Posted in All, Newly published ·

New review published in Seminars in Cell and Developmental Biology.

H. Y. Kim*, T. R. Jackson*, and L. A. Davidson (2016). On the role of mechanics in driving mesenchymal-to-epithelial transitions. (* contributed equally) Seminars in Cell and Developmental Biology.

 

Spreading of composite epithelial and mesenchymal tissues through 3D terrains.

2016-05-27 · Lance Davidson · 1,087 Comments · Posted in All, Newly published ·

New paper in Biomaterials by Song et al. How 3D substrates control spreading by epithelial-mesenchymal composite tissues.

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